In Vitro Anti-Acetylcholinesterase Activity of Dichloromethane Leaf Extracts of Carphalea glaucescens in Chilo partellus Larvae

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dc.contributor.authorNjoroge, A.W.
dc.contributor.authorNgugi, M.P.
dc.contributor.authorAliyu, U.
dc.contributor.authorMatheri, F.
dc.contributor.authorGitahi, M.S.
dc.contributor.authorMwangi, M.B.
dc.contributor.authorNjagi, M.J.
dc.contributor.authorMworia, J.K.
dc.contributor.authorNgure, G.M.
dc.date.accessioned2016-07-01T08:57:36Z
dc.date.available2016-07-01T08:57:36Z
dc.date.issued2016
dc.descriptionResearch Articleen_US
dc.description.abstractAcetlycholinesterase (AChE) hydrolyses the neurotransmitter acetylcholine resulting in the termination of nerve impulse at the synapse. Anti-acetylcholinesterase activities stop the passage of the nerve impulse at the synapse resulting in continuous stimulation which can lead to death. The manufacturers of many pesticides target the AChE because it interferes with the passage of the nerve impulse. In vitro study revealed that DCM leaf extract of Carphalea glaucescens has anti-acetylcholinesterase activity against crude acetlycholinesterase (AChE) enzyme extracted from Chilo partellus and an IC50 of 12.02 mg/ml was calculated. After qualitative phytochemical screening was carried out the phytochemicals which were present were tannins, phenols, flavonoids, steroids, terpenoids and alkaloidsen_US
dc.identifier.citationAnne NW, Piero NM, Umar A, Felix M, Maina GS, et al. (2016) In Vitro Anti-Acetylcholinesterase Activity of Dichloromethane Leaf Extracts of Carphalea glaucescens in Chilo partellus Larvae. Biochem Anal Biochem 5: 264. doi:10.4172/2161-1009.1000264en_US
dc.identifier.issn2161-1009
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14813
dc.language.isoenen_US
dc.publisherOMICS Internationalen_US
dc.subjectChilo partelluen_US
dc.subjectCarphalea glaucescensen_US
dc.subjectAnti-acetylcholinesteraseen_US
dc.titleIn Vitro Anti-Acetylcholinesterase Activity of Dichloromethane Leaf Extracts of Carphalea glaucescens in Chilo partellus Larvaeen_US
dc.typeArticleen_US
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