In Vitro Anti-Acetylcholinesterase Activity of Crude Fruits Sap Extract of Solanum incanum in Green Peach Aphids
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Date
2015
Authors
Umar, A.
Mgutu, A.J.
Piero, N.M.
Njoroge, A.W.
Njoroge, G.S.
Maina, M.B.
Muriithi, N.J.
Kiambi, M.J.
Mutero, N.G.
Mwonjoria, J.K.
Journal Title
Journal ISSN
Volume Title
Publisher
OMICS International
Abstract
Acetylcholinesterase is a key enzyme that terminates nerve impulses by catalyzing the hydrolysis of neurotransmitter,
acetylcholine, in the nervous system in various organisms. Irreversible inhibitors have been developed as insecticides
such as organophosphates and carbamates. Aqueous crude fruit sap extract of S. incanum was evaluated for
acetylcholinesterase activity in green peach aphids using Ellman’s method and is found active in inhibiting the ACHe of
green peach aphids. All tested concentrations of crude fruits sap extract of S. incanum possessed the ability to inhibit
acetylcholinesterase of green peach aphids at dose dependent manner and IC50 of 49.9 was calculated. This study
suggest that aqueous crude fruit sap extract of S. incanum inhibit the acetylcholinesterase of the green peach aphids
and it is possible the extract has compounds that increase both the level and duration of the neurotransmitter action.
Description
DOI:10.4172/2329-6631.1000142
Keywords
Acetylcholinesterase, Solanum incanum, Green peach aphids, Organophosphates