Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya

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dc.contributor.authorKasera, Gordon Ochieng’
dc.contributor.authorMaingi, John M
dc.contributor.authorOnyango, Omondi Kevin
dc.contributor.authorNyamache, Anthony Kebira
dc.date.accessioned2023-06-22T12:04:12Z
dc.date.available2023-06-22T12:04:12Z
dc.date.issued2021
dc.descriptionArticleen_US
dc.description.abstractBackground: Hepatitis A and B causes morbidity and mortality among patients. This study determined the proportion of hepatitis A, B viruses (HAV, HBV) and genetic diversity of HBV among jaundice patients at the Coast General Hospital, Mombasa County, Kenya. Methods: A cross-sectional study was conducted among 222 patients; recruited and screened for hepatitis B surface antigen (HBsAg) and anti-HAV IgM. Viral deoxyribonucleic acid (DNA) was extracted from positive samples; partial hepatitis B virus-pol (HBV-pol) gene amplified, directly sequenced and generated sequences phylogenetically analysed using MEGA X software. Demographic characteristics were compared in relation to HBV infection using Chi-square. Results: Forty-seven (21.2%) out of the 222 patients tested positive for HBV while no HAV was detected. Among those infected, n = 8 (3.6%) were females and n = 39 (17.6%) males. Forty-five samples amplified and sequenced successfully. However, two samples failed to amplify. Phylogenetic analysis revealed HBV A1 genotype [n = 35 (74.5%)] was most predominant. A3, B and C2 genotypes each occurred [n = 1 (0.02%)]. This study revealed co-existence of HBV A3, B and C2 genotypes that have not yet been detected in this region. Conclusion: HBV A1 genotype remains the predominant genotypes in this region. The detected HBV prevalence indicates possible high transmission with possibility of increasing trends of HBV genotypes based on revelation of existence of new genotypes in this region.en_US
dc.identifier.citationOchieng’Kasera, G., Maingi, J. M., Onyango, O. K., & Nyamache, A. K. (2021). Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya. The Malaysian Journal of Medical Sciences: MJMS, 28(3), 56.en_US
dc.identifier.otherhttps://doi.org/10.21315/mjms2021.28.3.5
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/25924
dc.language.isoenen_US
dc.publisherSchool of Medical Sciences, Universiti Sains Malaysiaen_US
dc.subjectprevalenceen_US
dc.subjectgenetic diversityen_US
dc.subjectHAVen_US
dc.subjectHBVen_US
dc.subjectjaundiceen_US
dc.titlePrevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenyaen_US
dc.typeArticleen_US
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