In Vitro Antiplasmodial Activity of Some Plants used in Kisii, Kenya Against Malaria and their Chloroquine Potentiation Effects.

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dc.contributor.authorMuregi, F. W.
dc.contributor.authorChhabra, S. C.
dc.contributor.authorNjagi, E.N.M.
dc.contributor.authorThoruwa, C. L.
dc.contributor.authorNjue, W. M.
dc.contributor.authorOrago, A. S.
dc.contributor.authorOmar, S. A.
dc.contributor.authorNdiege, I. O.
dc.date.accessioned2014-01-17T14:57:57Z
dc.date.available2014-01-17T14:57:57Z
dc.date.issued2003-02
dc.description.abstractFifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC50<100 μg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC50 values ranging less than 30 μg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC50 values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.en_US
dc.identifier.citationJournal of Ethnopharmacology Volume 84, Issues 2–3, February 2003, Pages 235–239en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/8668
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPlant extractsen_US
dc.subjectAntiplasmodialen_US
dc.subjectMedicinal plantsen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectsynergistic effecten_US
dc.titleIn Vitro Antiplasmodial Activity of Some Plants used in Kisii, Kenya Against Malaria and their Chloroquine Potentiation Effects.en_US
dc.typeArticleen_US
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