In Vitro Antiplasmodial Activity of Some Plants used in Kisii, Kenya Against Malaria and their Chloroquine Potentiation Effects.
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Date
2003-02
Authors
Muregi, F. W.
Chhabra, S. C.
Njagi, E.N.M.
Thoruwa, C. L.
Njue, W. M.
Orago, A. S.
Omar, S. A.
Ndiege, I. O.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC50<100 μg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC50 values ranging less than 30 μg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC50 values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.
Description
Keywords
Plant extracts, Antiplasmodial, Medicinal plants, Plasmodium falciparum, synergistic effect
Citation
Journal of Ethnopharmacology Volume 84, Issues 2–3, February 2003, Pages 235–239