| dc.contributor.author | Muregi, F. W. | |
| dc.contributor.author | Chhabra, S. C. | |
| dc.contributor.author | Njagi, E.N.M. | |
| dc.contributor.author | Thoruwa, C. L. | |
| dc.contributor.author | Njue, W. M. | |
| dc.contributor.author | Orago, A. S. | |
| dc.contributor.author | Omar, S. A. | |
| dc.contributor.author | Ndiege, I. O. | |
| dc.date.accessioned | 2014-01-17T14:57:57Z | |
| dc.date.available | 2014-01-17T14:57:57Z | |
| dc.date.issued | 2003-02 | |
| dc.identifier.citation | Journal of Ethnopharmacology Volume 84, Issues 2–3, February 2003, Pages 235–239 | en_US |
| dc.identifier.uri | http://ir-library.ku.ac.ke/handle/123456789/8668 | |
| dc.description.abstract | Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC50<100 μg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC50 values ranging less than 30 μg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC50 values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Plant extracts | en_US |
| dc.subject | Antiplasmodial | en_US |
| dc.subject | Medicinal plants | en_US |
| dc.subject | Plasmodium falciparum | en_US |
| dc.subject | synergistic effect | en_US |
| dc.title | In Vitro Antiplasmodial Activity of Some Plants used in Kisii, Kenya Against Malaria and their Chloroquine Potentiation Effects. | en_US |
| dc.type | Article | en_US |
