Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice
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Date
2016
Authors
Njogu, S.M.
Arika, W.M.
Nyamai, D.W.
Ngugi, M.P.
Machocho, Alex K.
Ngeranwa, J.J.N.
Njagi, E.N.M.
Journal Title
Journal ISSN
Volume Title
Publisher
OMICS International
Abstract
Maytenus putterkloides has been used traditionally to manage several diseases including diabetes, however, its
efficacy has not been scientifically evaluated. The aim of this study was to determine the in vivo hypoglycemic
activity of aqueous and ethyl acetate leaf extract of this plant in male swiss white albino mice. The antidiabetic
activity was screened in alloxan induced diabetic mice through oral and intraperitoneal routes. Phytochemical
composition was assessed using standard procedures. The aqueous and ethyl acetate leaf extract of this plant
showed hypoglycemic activity at dose levels of 50, 100, 200, 300 mg/kg body weight in a dose independent manner
via both routes. The extracts contained total phenolics, saponins, tannins, flavonoids, alkaloids and phytonutrients;
vitamins B1, B3, and C. The observed hypoglycemic activity could be associated with the phytochemicals present in
this plant extract.
Description
Research Article
Keywords
Diabetes mellitus, Maytenus putterkloides, Hypoglycemic activity, Antidiabetic, Alloxan
Citation
Njogu SM, Arika WM, Nyamai DW, Ngugi MP, Machocho AK, et al. (2016) Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice. J Diabetes Metab 7: 685. doi:10.4172/2155-6156.1000685