Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice

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dc.contributor.authorNjogu, S.M.
dc.contributor.authorArika, W.M.
dc.contributor.authorNyamai, D.W.
dc.contributor.authorNgugi, M.P.
dc.contributor.authorMachocho, Alex K.
dc.contributor.authorNgeranwa, J.J.N.
dc.contributor.authorNjagi, E.N.M.
dc.date.accessioned2016-08-24T10:05:50Z
dc.date.available2016-08-24T10:05:50Z
dc.date.issued2016
dc.descriptionResearch Articleen_US
dc.description.abstractMaytenus putterkloides has been used traditionally to manage several diseases including diabetes, however, its efficacy has not been scientifically evaluated. The aim of this study was to determine the in vivo hypoglycemic activity of aqueous and ethyl acetate leaf extract of this plant in male swiss white albino mice. The antidiabetic activity was screened in alloxan induced diabetic mice through oral and intraperitoneal routes. Phytochemical composition was assessed using standard procedures. The aqueous and ethyl acetate leaf extract of this plant showed hypoglycemic activity at dose levels of 50, 100, 200, 300 mg/kg body weight in a dose independent manner via both routes. The extracts contained total phenolics, saponins, tannins, flavonoids, alkaloids and phytonutrients; vitamins B1, B3, and C. The observed hypoglycemic activity could be associated with the phytochemicals present in this plant extract.en_US
dc.identifier.citationNjogu SM, Arika WM, Nyamai DW, Ngugi MP, Machocho AK, et al. (2016) Hypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Mice. J Diabetes Metab 7: 685. doi:10.4172/2155-6156.1000685en_US
dc.identifier.issn2155-6156
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14897
dc.language.isoenen_US
dc.publisherOMICS Internationalen_US
dc.subjectDiabetes mellitusen_US
dc.subjectMaytenus putterkloidesen_US
dc.subjectHypoglycemic activityen_US
dc.subjectAntidiabeticen_US
dc.subjectAlloxanen_US
dc.titleHypoglycemic Effect of Aqueous and Ethyl Acetate Leaf Extract of Maytenus putterkloides in Alloxan Induced Diabetic Miceen_US
dc.typeArticleen_US
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