Anti-inflammatory activity of craterostigma pumilum (hochst) is associated with hyperalgesia

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dc.contributor.authorMwonjoria, K. J.
dc.contributor.authorUmar, Aliyu
dc.contributor.authorJuma, Kevin K.
dc.contributor.authorKahiga, Titus M.
dc.contributor.authorNgugi, Piero M.
dc.contributor.authorMburu, David
dc.contributor.authorWanyonyi, A. W.
dc.contributor.authorGithinji, Charles G.
dc.contributor.authorNgeranwa, J.J.N.
dc.date.accessioned2016-08-31T09:21:34Z
dc.date.available2016-08-31T09:21:34Z
dc.date.issued2016-01
dc.descriptiondoi: 10.14419/ijpt.v4i2.6497en_US
dc.description.abstractInflammation and pain are ubiquitous signs and symptoms of a large number of ailments affecting humanity. There are equally as many methods and substances that are used as remedies for the conditions. Examples of remedies used include herbal extracts such those of genus Craterostigma among others. In Kenya, some plants from this genus are used as folklore remedy for toothache, joint and muscle pains. Interestingly, in spite of their use, there is no scientific study that has been instituted to evaluate their efficacy. The current study evaluated the anti-inflammatory and antinociceptive effect of both dichloromethane (DCM) and aqueous extract of Craterostigma pumilum using animal models. The anti-inflammatory and antinociceptive effect assays were carried out using formalin induced pedal edema and pain test respectively in white Wister rats. The phytochemical profile of the plant extract was carried out using standard procedures. Both DCM and aqueous extracts exhibited highly significant anti-inflammatory (p < 0.001) effects but no antinociceptive effects. However, the DCM extract showed a very significant (p < 0.001) hyperalgesia. The study renders support to folklore use of the plant for inflammation however it recommends incorporation of an analgesic remedy in the process.en_US
dc.identifier.citationInternational Journal of Pharmacology and Toxicology, 4:2, 2016 pg. 169-173, www.sciencepubco.com/index.php/IJPT doi: 10.14419/ijpt.v4i2.6497en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14905
dc.language.isoenen_US
dc.publisherScience Publishing Corporationen_US
dc.subjectCraterostigmaen_US
dc.subjectPumilumen_US
dc.subjectInflammationen_US
dc.subjectHyperalgesiaen_US
dc.subjectFlavonoidsen_US
dc.titleAnti-inflammatory activity of craterostigma pumilum (hochst) is associated with hyperalgesiaen_US
dc.typeArticleen_US
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