Exploring the Dynamic Role of Gamma-Delta T Cells in Clinical Pathology: A Systematic Review of Current Knowledge and Future Perspectives
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Date
2023-09
Authors
Asamba, Micah Nyabiba
Wepukhulu, Miriam
Momo, G. Stevens
Journal Title
Journal ISSN
Volume Title
Publisher
EANSO
Abstract
Gamma-delta [γδ] T cells are a significant subset of T cells with ability to
recognize many antigens without the guidance of major histocompatibility
complex (MHC) molecules. A lot of studies have been conducted on them
ever since they were discovered 36 years ago. Advances have been made
about their structure and function. Thus, there is a need for an up-to-date
review about their significance as well as their roles in Multiple Sclerosis. The
study aimed to provide an up-to-date knowledge concerning gamma delta T
cells in pathogenesis of Multiple Sclerosis (MS). A systematic review
methodology was used to scope information from recent studies about gamma
delta T cells. The review was carried out in PubMed database and it followed
the PRISMA guidelines. The computerized review yielded 60 peer-reviewed
articles published between 2011 and 2020. The results showed that gamma
delta cells play a critical role in protection against infections and the fight
against malignant cells. Most of the reviewed studies highlighted recent
advances in research. It was noted that the subset of T cells plays a role in
pathogenesis of MS. Several studies have highlighted the protective and
detrimental effects of γδ T cells. On the one hand, the cells contribute to the
pathogenesis of MS, while, on the other hand, they also help in
immunoregulation. However, there is a dearth of literature on their specific
role and their mechanism of action. Therefore, further studies are needed
about γδ T cells in both human and animal model studies. Based on the
findings of the reviewed studies, there is great promise in the use of γδ T cells
for MS immunotherapy.
Description
Article
Keywords
Gamma-Delta T Cells, Multiple Sclerosis, Immunoregulation, Pathogenesis, Immunotherapy, Malignant Cells, Major Histocompatibility Complex
Citation
Asamba, M. N.,Wepukhulu, M. & Stevens, M. G. (2023). Exploring the Dynamic Role of Gamma-Delta T Cells in Clinical Pathology: A Systematic Review of Current Knowledge and Future PerspectivesEast African Journal of Health and Science, 6(1), 402-414. https://doi.org/10.37284/eajhs.6.1.1394.
URI
Asamba, M. N.,Wepukhulu, M. & Stevens, M. G. (2023). Exploring the Dynamic Role of Gamma-Delta T Cells in Clinical Pathology: A Systematic Review of Current Knowledge and Future PerspectivesEast African Journal of Health and Science, 6(1), 402-414. https://doi.org/10.37284/eajhs.6.1.1394.
http://ir-library.ku.ac.ke/handle/123456789/27002
http://ir-library.ku.ac.ke/handle/123456789/27002