Biochemical Markers Of In Vivo Hepatotoxicity
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Date
2016
Authors
Arika, Wm
Nyamai, Dw
Osano Ko, Mp
Njagi, Enm
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Clinical Toxicology
Abstract
A chemical compound, whether of natural or of synthetic origin, brings about a toxicological effect when its dose
is high enough or the duration of exposure is sufficient to cause an alteration in the normal homeostasis of body
fluids and tissues. Therefore, the right dose differentiates a toxicant from a remedy. The body detoxifies drugs and
other chemical compounds through key organs such as the liver. The liver plays a central role in the metabolism and
excretion of xenobiotics which makes it highly susceptible to their adverse and toxic effects. These effects can be
manifested in the form of hepatic injuries, which take many forms from cellular degeneration and necrosis to
cirrhosis or cholestasis to vascular injury. Exposure to hepatotoxicants alters the homeostatic balance of various
biological markers that provides a powerful and dynamic approach to understanding the spectrum of liver diseases.
These markers offer a means for homogeneous classification of a disease and risk factor, and they can extend one's
basic information about the underlying pathogenesis of disease and in drug design.
Description
Article
Keywords
Biological markers, ALT, AST, ALP, γ GT, LDH, CK, rubin, α-Amylase, Cholesterol, glucose
Citation
Arika, W. M., Nyamai, D. W., Osano, K. O., Ngugi, M. P., & Njagi, E. N. M. (2016). Biochemical markers of in vivo hepatotoxicity. J Clin Toxicol, 6(2), 1-8.