Bioactive Metabolites from Trichoderma Harzianum and Trichoderma Longibrachiatum
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Date
2003-03
Authors
Thoruwa, C. L.
Tarus, P. K.
Wanyonyi, A. W.
Chhabra, S. C.
Journal Title
Journal ISSN
Volume Title
Publisher
Chemical Society of Ethiopia
Abstract
The tea plant, Camellia sinensis (L.) O. Kuntze is an important crop in the
agriculturally based economy of Kenya. Many diseases affect the tea plant but the most prevalent
is armillaria root rot caused by the fungus Armillaria mellea. Compounds from the fermentation of
Trichoderma species in different media were bioassayed against some selected gram-positive and
gram-negative bacteria, fungi including Armillaria mellea, a yeast and a Mucor. Compounds
obtained from T. harzianum, and T. longibrachiatum when cultured in various media were
investigated individually for in-vitro antifungal and antibacterial activities by agar diffusion
technique. Some of the compounds produced definite antifungal and antibacterial activities. 2-
Phenylethanol (1) and tyrosol (2) obtained from T. harzianum are reported for the first time from
Trichoderma species. The most active metabolite isolated from these strains was 6-n-pentyl-•-
pyrone (3), which showed the highest antifungal and antibacterial activity and completely
inhibited the growth of Armillaria mellea fungus at a concentration of 200 ppm. Compound 4
(sorbicillin) exhibited moderate activity against the fungal test organisms.
Description
Keywords
Trichoderma harzianum, Trichoderma longibrachiatum, 2-Phenylethanol, Tyrosol, 6-n-Pentyl-•-pyrone, Armillaria Mellea
Citation
Bull. Chem. Soc. Ethiop. 2003, 17(2), 185-190.