Phytochemical Characterization of Dichloromethane Stem Bark Extract of Piliostigma thonningii (Schum.)
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Date
2023-09
Authors
Okioga, Farida Moraa
Ngugi, Mathew P.
Makonde, Huxley Mae
Journal Title
Journal ISSN
Volume Title
Publisher
IJISRT
Abstract
Piliostigma thonningii (Schum.) commonly
referred to as monkey bread belongs to Fabaceae family
and is used in the tropics for medicinal and nutritional
uses. The plant is utilized for management of human
ailments among them rheumatism, malaria, fever, snake
bites and dysentery. It is widely acknowledged that plant
pharmacological activities are driven by their secondary
metabolites. Identification of the metabolites has led to
drug discovery and leads for designing of novel
compounds to enhance human health. Though P.
thonningii is endowed with numerous bioactivities, there
is minimal literature detailing the phytochemicals
responsible for its therapeutic efficacies. For that reason,
the present embarked on quantitative phytochemical
characterization of DCM stem bark extract of P.
thonningii. The analysis was carried out using gas
chromatography-mass spectrometry. The results showed
that the extract contained various classes of
phytocompounds including flavonoids, phenolics,
phytosterols and fatty acids. The most abundant
compounds found in the extract were oleic acid and
squalene whereas valencene and α-cedrene were the least
concentrated. The compound identified in the extract
have been reported to possess numerous pharmacological
efficacies such as analgesic, anti-inflammatory, anticancer
and antidiabetic activities. Thus, the promising
therapeutic potential of P. thonningii is attributed to these
phytocompounds. The study recommends further
research to isolate and purify the activity ingredient from
P. thonningii as well as determine their mechanism of
action.
Description
Article
Keywords
P. thonningii, Phytochemicals, gas chromatography-mass spectrometry
Citation
Okioga, F. M., Ngugi, M. P., & Makonde, H. M. Phytochemical Characterization of Dichloromethane Stem Bark Extract of Piliostigma thonningii (Schum.).