Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenya

Simple item page
dc.contributor.authorNchagwa, Edward Mangare
dc.contributor.authorMuturi, Margaret W.
dc.contributor.authorGachara, George
dc.date.accessioned2021-09-17T11:58:53Z
dc.date.available2021-09-17T11:58:53Z
dc.date.issued2018
dc.descriptionA research article published in Open Journal of Immunologyen_US
dc.description.abstractCytomegalovirus (CMV) is an important pathogen in immunocompromised individuals. Coupled with Human Immunodeficiency Virus (HIV), it causes end organ diseases leading to increased morbidity and mortality in the population. The prevalence of Cytomegalovirus infection is above 93% in HIV infected children in Kenya. Despite, a high Cytomegalovirus seroprevalence found in children, few studies have documented CMV in adults. This study was done to determine the seroprevalence of CMV infection and its associated risk factors among HIV patients attending Thika level 5 Hospital in Kiambu County, Kenya. The study also evaluated the effect CMV infection on the immunity of HIV infected patients. A cross-sectional study involving 163 HIV positive participants from different age groups was carried out. A questionnaire was used to assess the socio-demographic and specific risk factors associated with cytomegalovirus. Blood was collected and analyzed for CD4 counts, CMV IgG and IgM. The seroprevalence of CMV was found to be 89% (CMV IgG) while the incidence was 10.4% (CMV IgM). The study found that CMV infection leads to more suppression of the immunity among the HIV infected patients. In addition, education, economic status, having other sexual transmitted infections, sharing drinks, immune status and blood transfusion were associated with CMV infection (p < 0.05). The study recommends adoption of CMV screening services and education on CMV risk factors as CMV infection preventive strategies.en_US
dc.identifier.citationMangare, N.E., Muturi, M.W. and Gachara, G. (2018) Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenya. Open Journal of Immunology, 8, 1-12. https://doi.org/10.4236/oji.2018.81001en_US
dc.identifier.issnOnline: 2162-4526
dc.identifier.issnPrint: 2162-450X
dc.identifier.urihttps://www.scirp.org/journal/paperinformation.aspx?paperid=84888
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/22505
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.subjectCytomegalovirusen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectImmunoglobulin G and Men_US
dc.titleSeroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenyaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors.pdf
Size:
308.1 KB
Format:
Adobe Portable Document Format
Description:
Full text article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Deparment of Medical Laboratory Sciences