Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenya
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Date
2018
Authors
Nchagwa, Edward Mangare
Muturi, Margaret W.
Gachara, George
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Research Publishing
Abstract
Cytomegalovirus (CMV) is an important pathogen in immunocompromised
individuals. Coupled with Human Immunodeficiency Virus (HIV), it causes
end organ diseases leading to increased morbidity and mortality in the population. The prevalence of Cytomegalovirus infection is above 93% in HIV infected children in Kenya. Despite, a high Cytomegalovirus seroprevalence
found in children, few studies have documented CMV in adults. This study
was done to determine the seroprevalence of CMV infection and its associated
risk factors among HIV patients attending Thika level 5 Hospital in Kiambu
County, Kenya. The study also evaluated the effect CMV infection on the
immunity of HIV infected patients. A cross-sectional study involving 163 HIV
positive participants from different age groups was carried out. A questionnaire was used to assess the socio-demographic and specific risk factors associated with cytomegalovirus. Blood was collected and analyzed for CD4
counts, CMV IgG and IgM. The seroprevalence of CMV was found to be 89%
(CMV IgG) while the incidence was 10.4% (CMV IgM). The study found that
CMV infection leads to more suppression of the immunity among the HIV
infected patients. In addition, education, economic status, having other sexual
transmitted infections, sharing drinks, immune status and blood transfusion
were associated with CMV infection (p < 0.05). The study recommends adoption of CMV screening services and education on CMV risk factors as CMV
infection preventive strategies.
Description
A research article published in Open Journal of Immunology
Keywords
Cytomegalovirus, Human Immunodeficiency Virus, Immunoglobulin G and M
Citation
Mangare, N.E., Muturi, M.W. and Gachara, G. (2018) Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenya. Open Journal of Immunology, 8, 1-12. https://doi.org/10.4236/oji.2018.81001