Snake-Antivenom Activities of Aqueous Extracts Of Amaranthus Spinosus L. Against Naja Subfulva Venom

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dc.contributor.authorYego, Kennedy K.
dc.contributor.authorNjagi, Eliud N.M.
dc.contributor.authorOrinda, George O.
dc.contributor.authorGikunju, Joseph K.
dc.date.accessioned2023-06-08T13:49:57Z
dc.date.available2023-06-08T13:49:57Z
dc.date.issued2022-12
dc.descriptionresearch articleen_US
dc.description.abstractThe present management regime of snake bites requires the use of anti-venom immunoglobulins (Igs). However, these anti-venoms have the limitations of being expensive, requiring cold storage facilities, and having problems of hypersensitivity reactions in some individuals. Amaranthus spinosus plant medicine has traditionally been used in managing snake bites in Uasin-Gishu County, Kenya. However, its efficacy has not been scientifically validated. Therefore, this study aimed to determine in vivo and in vitro the efficacy of the medicinal plant against Naja subfulva venom using the mouse model, agarose-erythrocyte-egg yolk gel plate, and human-citrated plasma methods. The antivenom studies suggest that the aqueous plant extracts possess antivenom activity against N. subfulva venom both in vivo and in vitro. In conclusion, this study confirmed that aqueous extracts of Amaranthus spinosus were effective in neutralizing in vivo and in vitro snake venom activity of Naja subfulva.en_US
dc.identifier.citationYego, K. K., Njagi, E. N., Orinda, G. O., & Gikunju, J. K. Snake-Antivenom Activities of Aqueous Extracts of Amaranthus spinosus L. Against Naja subfulva Venom. methods, 10, 11.en_US
dc.identifier.issn2456-2165
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/25733
dc.language.isoenen_US
dc.subjectMedian effective dose (ED50)en_US
dc.subjectMedian lethal dose (LD50)en_US
dc.subjectPhospholipase A2en_US
dc.subjectToxicityen_US
dc.subjectPhytochemicalsen_US
dc.titleSnake-Antivenom Activities of Aqueous Extracts Of Amaranthus Spinosus L. Against Naja Subfulva Venomen_US
dc.typeArticleen_US
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