Antinociceptive Potential of Methanol Leaf Extracts of Cissampelos Parreira (Linn), Lantana Camara (Linn) and Ocimum Gratissimum (African Basil)

Simple item page
dc.contributor.authorKimuni, Susan Nyawira
dc.contributor.authorGitahi, Stephen Maina
dc.date.accessioned2021-08-17T06:05:02Z
dc.date.available2021-08-17T06:05:02Z
dc.date.issued2021
dc.descriptionAn Article Published in Journal of Advanced Biotechnology and Experimental Therapeuticsen_US
dc.description.abstractThe effects of Cissampelos pareira (Linn), Lantana camara (Linn) and Ocimum gratissimum (African basil) leaf extracts on pain have not been biologically determined despite their frequent traditional use in pain management. The present study evaluated the effects of methanol leaf extracts of these three plants on formalin-induced pain in Swiss albino mice. Leaves of C. pareira, L. camara, and O. gratissimum were harvested, cleaned, shade dried, crushed, extracted in absolute methanol and concentrated to dryness. The quantitative phytochemical screening of the three plant extracts was first carried out. Then, the pain assay tests constituted eight groups of five mice each: normal control group, positive control group, negative control group and experimental groups of 50, 100, 150, 200 and 250 mg/kg bw extracts. The animals were administered with various treatments thirty minutes before induction of pain through injection of 0.01 ml of 2.5% formalin solution into the sub-plantar region of the left hind paw. Paracetamol at the dose of 50 mg/kg bw and 5% dimethyl sulfoxide were used as the positive and negative controls respectively. The plant extracts were administered intraperitoneally and orally. Data was analyzed using one-way analysis of variance and unpaired t-test. Phytochemical screening on separate extracts of C. pareira, L. camara, and O. gratissimum revealed fatty acids, phenols, flavonoids and terpenoids. The different dosages of methanol leave extracts of C. pareira, L. camara, and O. gratissimum reduced pain significantly (p˃0.05) in mice. The significant reduction of pain was associated with fatty acids, phenols, flavonoids and terpenoids revealed in the plant extracts.en_US
dc.identifier.issn2616-4760
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/22432
dc.language.isoenen_US
dc.publisherBangladesh Society for Microbiology, Immunology, and Advanced Biotechnology (BSMIAB)en_US
dc.subjectAntinociceptionen_US
dc.subjectCissampelos pareiraen_US
dc.subjectLantana camaraen_US
dc.subjectOcimum gratissimumen_US
dc.subjectPhytochemicals.en_US
dc.titleAntinociceptive Potential of Methanol Leaf Extracts of Cissampelos Parreira (Linn), Lantana Camara (Linn) and Ocimum Gratissimum (African Basil)en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Antinociceptive potential of methanol......pdf
Size:
1.09 MB
Format:
Adobe Portable Document Format
Description:
Full Text Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Biochemistry and Biotechnology