Risk Factors of Severe Hepatotoxicity among HIV-1 Infected Individuals Initiated on Highly Active Antiretroviral Therapy in the Northwest Region of Cameroon

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dc.contributor.authorAbongwa, Lem Edith
dc.contributor.authorNyamache, Anthony Kebira
dc.contributor.authorFokunang, Charles
dc.contributor.authorTorimiro, Judith
dc.contributor.authorEmmanuel, Nshom
dc.contributor.authorDomkam, Irénée
dc.contributor.authorEyongetah, Mbu
dc.contributor.authorJude, Beriyuy
dc.contributor.authorMua, Fung Holgar
dc.contributor.authorBella, Sama
dc.contributor.authorTamboh, Tankou Colman
dc.contributor.authorMoungang, Erna Charlene
dc.contributor.authorNgum, Victorine
dc.contributor.authorOkemo, Paul
dc.date.accessioned2023-07-12T09:34:46Z
dc.date.available2023-07-12T09:34:46Z
dc.date.issued2022
dc.descriptionArticleen_US
dc.description.abstractBackground: Hepatotoxicity due to highly active antiretroviral therapy (HAART) has gained prominent attention since it can be afected by many factors. The aim of this study was to determine the prevalence of hepatotoxicity and related risk factors of severe hepatotoxicity following HAART initiation. Methods: A total of 100 drug-naive patients aged between 18 and 61 years were recruited. They were put on Tenofovir/Lamivudine/Efavirenz [TDF/3TC/EFV] (64), Zidovudine/ Lamivudine/Efavirenz [AZT/3TC/EFV] (22), and Zidovudine/ Lamivudine/Nevirapine AZT/3TC/NVP (14) and monitored for 6months and blood samples drawn.Alanine aminotransferases (ALT), aspartate aminotransferases (AST), and alkaline phosphatase (ALP) wereanalyzed by enzymatic methods and used to classify levels of hepatotoxicity. Results: A total of 37(37%) and 49(49%) patients presented with hepatotoxicity while 15% and 28% had severe hepatotoxicity at 4 and 24 weeks respectively. Serum levels of all enzymes increased signifcantly (p=0.001) with increased treatment duration. Univariate analysis revealed that the risk factor of developing severe hepatotoxicity was signifcantly greater in patients<30years (p=0.02), males(p=0.04), low BMI (p=0.02), low monthly income (p=0.01) earners, and patients on AZT+3TC+NVP regimen (p=0.01). While multivariate analysis at p<0.09 showed that age 30–40 years, low BMI, low monthly income, and the use of AZT+3TC+NVP regimen were independent risk factors. Conclusions: Low BMI, age group of 30–40years, low monthly income, and the use of AZT+3TC+NVP regimen identifed as risk factors for the development of severe hepatotoxicity should be considered as an important strategy by clinicians in preventing the hepatotoxicity.en_US
dc.identifier.citationAbongwa, L. E., Nyamache, A. K., Charles, F., Torimiro, J., Emmanuel, N., Domkam, I., ... & Okemo, P. (2022). Risk factors of severe hepatotoxicity among HIV-1 infected individuals initiated on highly active antiretroviral therapy in the Northwest Region of Cameroon. BMC gastroenterology, 22(1), 1-8.en_US
dc.identifier.urihttps://doi.org/10.1186/s12876-022-02305-x
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/26172
dc.language.isoenen_US
dc.publisherBMC Gastroenterologyen_US
dc.subjectRisk factorsen_US
dc.subjectLiver enzymesen_US
dc.subjectHAARTen_US
dc.subjectHIV-1en_US
dc.subjectHepatotoxicityen_US
dc.titleRisk Factors of Severe Hepatotoxicity among HIV-1 Infected Individuals Initiated on Highly Active Antiretroviral Therapy in the Northwest Region of Cameroonen_US
dc.typeArticleen_US
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