Analysis of genetic variability in Anopheles arabiensis and Anopheles gambiae using microsatellite loci
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Date
2003-09-10
Authors
Orango, S.
Field, L. M.
James, A.
Kamau, L.
Mukabana, W. R.
Hawley, W. A.
Lehmann, T.
Irungu, L. W.
Collins, F. H.
Journal Title
Journal ISSN
Volume Title
Publisher
WILEY
Abstract
We analysed genetic variability in Anopheles arabiensis and Anopheles gambiae populations using micro-satellite loci to determine whether the Rift Valley restricts the flow of genes. Deviations from Hardy–Weinberg expectations were significant, and were most likely to be due to the high frequency of null alleles observed. An. arabiensis populations occurring between 40 and 700 km apart across the Eastern arm of the Rift Valley were not differentiated (pair-wise Fst range: 0.0033–0.0265, P > 0.05). Neither were An. gambiae populations from Asembo Bay and Ghana (Fst: 0.0063, P > 0.05) despite a geographical separation of about 5000 km. In contrast, significant differentiation was observed between An. gambiae populations from Asembo Bay and Kilifi (about 700 km apart; FST= 0.1249, P < 0.01), suggesting the presence of a barrier to gene flow.
Description
http//DOI:10.1046/j.1365-2583.1999.820287.x
Keywords
Anopheles arabiensis, Anopheles gambiae, genetic variability, microsatellite loci, population genetics
Citation
Insect Molecular Biology Volume 8, Issue 2, pages 287–297, May 1999