Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)

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dc.contributor.authorMbiri, J.W.
dc.contributor.authorKasili, S.
dc.contributor.authorMbinda, W.
dc.contributor.authorKisangau, P.D.
dc.contributor.authorNgugi, M.P.
dc.date.accessioned2016-10-05T07:39:19Z
dc.date.available2016-10-05T07:39:19Z
dc.date.issued2016
dc.descriptionResearch Articleen_US
dc.description.abstractThe conventional drugs used to manage fever are usually not affordable, not easily available and have adverse side effects. Alternative therapeutic agents, like medicinal plant derivatives, should therefore be developed because they have been reported to be more affordable, more readily available and have lesser side effects. Terminalia brownii is traditionally used to manage fever but this ethno-medicinal claim lacks scientific validation. The present study therefore evaluated the anti-pyretic activity of T. brownii in Wistar rats. Fresh bark samples of T. brownii were collected from Kitui County, Kenya. This study used 30 adult male Wister rats that were 2-3 months old and weighing 140-180 g was used for the experiments. Steam-distilled turpentine was the pyrogen used to induce pyrexia and Aspirin was used as the reference drug. The extract reduced the elevated rectal temperatures by between 1.15- 4.38% while aspirin reduced the elevated rectal temperatures by between 0.00-4.85%. The present study showed a significant dose-dependent anti-pyretic activity of methanolic bark extracts of T. brownii hence validating its folklore use as a fever remedy.en_US
dc.identifier.citationMbiri JW, Kasili S, Mbinda W, Kisangau PD, Piero NM (2016) Anti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus). J Pharmacogn Nat Prod 2: 121. doi:10.4172/2472-0992.1000121en_US
dc.identifier.issn2472-0992
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/15100
dc.language.isoenen_US
dc.publisherOMICS Internationalen_US
dc.subjectAnti-pyretic activityen_US
dc.subjectAspirinen_US
dc.subjectMethanolic bark extractsen_US
dc.subjectTerminalia browniien_US
dc.titleAnti-Pyretic Properties of Methanolic Bark Extracts of Terminalia brownii in Wistar Rats (Rattus novegicus)en_US
dc.typeArticleen_US
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