Comparative genetics of alcoholism in the Kenyan populations

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dc.contributor.authorDoudoladova, K. E.
dc.contributor.authorNdiritu, D
dc.contributor.authorOchieng, David
dc.date.accessioned2014-11-25T11:41:30Z
dc.date.available2014-11-25T11:41:30Z
dc.date.issued2004
dc.description.abstractHepatic alcohol dehydrogenase and aldehyde dehydrogenase are major enzymes in the metabolism of exogenous ethanol. These enzymes are polymorphic and are involved in alcohol drinking and risk of alcoholism in some world populations. Three hundred and seventy one samples of hair root lyzates from five Kenyan communities were screened for ADH 2, ADH 3 and ALDH 2 polymorphisms via isoelectric focusing. Additional information on alcohol drinking behaviour, alcohol intake, frequency of alcohol drinking, preference of alcoholic drinks, and alcohol dependence was collected via interview and questionnaire. SAS JPIN statistical program was used to analyze obtained data using chi-square, Anova and t-tests. The results showed that ADH 2*2, ADH 3*1 and ALDH 2*2 alleles do not have protective properties against risk of alcoholism in the selected Kenyan populations. Other factors than ADH and ALDH polymorphisms interfered in the protective mechanism of the latter alleles against excessive alcohol drinking.en_US
dc.description.sponsorshipThe work was supported by grants from Kenyatta University Faculty of Science Deans Committee. Biochemical analyses was done in Yakut State University Faculty of Biologyen_US
dc.identifier.citationAfrican Journal of Biotechnology Vol. 3 (2), pp. 152-155, February 2004en_US
dc.identifier.issnhttp://www.academicjournals.org/AJB
dc.identifier.issn1684–5315
dc.identifier.other1684-5315
dc.identifier.urihttp://www.ajol.info/index.php/ajb/article/download/14933/58844
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11739
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectAlcoholen_US
dc.subjectADHen_US
dc.subjectALDHen_US
dc.subjectpolymorphismen_US
dc.subjectalcohol drinkingen_US
dc.subjectalcoholism.en_US
dc.titleComparative genetics of alcoholism in the Kenyan populationsen_US
dc.typeArticleen_US
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