Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats

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dc.contributor.authorKamau, J.K.
dc.contributor.authorNthiga, P.M.
dc.contributor.authorSafari, V.C.
dc.contributor.authorNjagi, S.M.
dc.contributor.authorMwonjoria, J.K.
dc.contributor.authorNgugi, M.P.
dc.contributor.authorNgeranwa, J.J.N.
dc.date.accessioned2016-07-01T07:57:40Z
dc.date.available2016-07-01T07:57:40Z
dc.date.issued2016
dc.descriptionResearch Articleen_US
dc.description.abstractSynthetic antipyretic drugs are not readily accessible and have adverse side effects. Herbal medicines possess bioactive compounds that are safer and efficient in the management of various diseases and disorders. Acacia hockii and Kigelia africana are traditionally used to manage pyrexia among the Embu and Mbeere communities in Kenya but lack scientific data to validate their use. The present study evaluated for the antipyretic activity of the A. hockii and K. africana in rat models to scientifically validate their traditional use. The plant samples were collected with the help of local herbalists in Embu County, Kenya and transported to Kenyatta University for cleaning, air drying, milling, and extraction. Adult male Wistar rats were randomly divided into six groups of 5 animals each; normal control, positive control, negative control, and three experimental groups. The antipyretic effect was assessed using turpentine-induced pyrexia method. The antipyretic activities of the extracts were compared to reference drug aspirin. The stem bark extract of A. hockii reduced the raised rectal temperature by between 0.62-3.88% while the stem bark extract of K. africana reduced the elevated rectal temperature by between 0.06-3.07%. The reference drug aspirin reduced the rectal temperature of pyretic rats by between 0.63-3.1%. The qualitative phytochemical screening of the two extracts indicated the presence of flavonoid, alkaloids, steroids, saponins, terpenoids which are associated with the antipyretic activity. The present study demonstrated potent antipyretic activities of methanolic extracts of A. hockii and K. africana in a dose-dependent manner after the second hour of the treatment period, which supports their traditional use. The present study, therefore, recommends the ethnomedicinal use of K. africana and A. hockii in the management of pyrexiaen_US
dc.identifier.citationKamau JK, Nthiga PM, Safari VC, Njagi SM, Mwonjoria JK, et al. (2016) Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats. J Pharmacogn Nat Prod 2: 118. doi:10.4172/2472-0992.1000118en_US
dc.identifier.issn2472-0992
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14812
dc.language.isoenen_US
dc.publisherOMICS Internationalen_US
dc.subjectKigelia africanaen_US
dc.subjectAcacia hockiien_US
dc.subjectPyrexiaen_US
dc.subjectTurpentineen_US
dc.subjectPGE2en_US
dc.titleAntipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Ratsen_US
dc.typeArticleen_US
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