Phytochemical Profile of Prunus africana Stem Bark from Kenya

Simple item page
dc.contributor.authorNyamai, D.W.
dc.contributor.authorMawia, A.M.
dc.contributor.authorWambua, F.K.
dc.contributor.authorNjoroge, A.
dc.contributor.authorMatheri, F.
dc.contributor.authorLagat, R.
dc.contributor.authorKiambi, J.
dc.contributor.authorOgola, P.
dc.contributor.authorArika, W.M.
dc.contributor.authorCheseto, X.
dc.contributor.authorKing’ori, E.
dc.contributor.authorRamni, J.
dc.contributor.authorNgugi, M.P.
dc.contributor.authorMuchugi, A.
dc.contributor.authorNg’ang’a, M.
dc.contributor.authorBurugu, M.W.
dc.date.accessioned2015-12-14T09:19:28Z
dc.date.available2015-12-14T09:19:28Z
dc.date.issued2015
dc.descriptionDOI:10.4172/jpnp.1000110en_US
dc.description.abstractPrunus africana (Hook.f.) is an evergreen tree that grows in African mountains. P. africana species’ bark and bark extracts are used for the treatment of benign prostate hyperplasia. The pharmacological efficacy of the extracts is believed to be due to synergistic effect of several compounds such as phytosterols, pentacyclic triterpenoids and ferulic acid esters. High demand for the bark and bark extracts of P. africana has led to over-exploitation of the natural population resulting to it being listed as an endangered species; Appendix II of CITES. Conservation of the species can be done through domestication. However, growth factors need to be established first to ensure success of on-farm production. With this in mind, the World Agroforestry Centre established a P. africana stand at Muguga, Kenya to evaluate the species phytochemical profile and yields. Phytochemistry profiling was carried out using Liquid Chromatography coupled to Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS). Myristic acid, linoleic acid, lauric acid, methyl myristate, methyl laurate and methyl linoleate were the major compounds present after analysis of essential oils in the bark samples while campesterol, β-sitosterol, lup-20(29)-en-3-one, palmitic acid, β-sitostenone, (3.β.,5.α)- stigmast-7-en-3-ol, stigmastan-3,5-diene and α-tocopherol were detected in dichloromethane and hexane extracts of the three populations. In methanolic extract we detected cyanidin-O-galactoside, cyanidin-3-O-rutinoside, procyanidin B5, robinetinidol- (4-α-8) catechin-(6,4-α)robinetinol and ursolic acid.. All these compounds have been reported to have salutary benefits in humans. The phytochemical data has important implications in coming up with strategies for sustainable harvesting and conservation of this species as well as its management on-farm.en_US
dc.identifier.citationJ Pharmacogn Nat Prod 2015, 1:1en_US
dc.identifier.issnJPNP
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/13982
dc.language.isoenen_US
dc.publisherThe American Society of Pharmacognosyen_US
dc.subjectPrunus africanaen_US
dc.subjectPhytochemistryen_US
dc.subjectPhytotherapyen_US
dc.subjectBenign prostate hyperplasiaen_US
dc.titlePhytochemical Profile of Prunus africana Stem Bark from Kenyaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Phytochemical Profile of Prunus......pdf
Size:
915.69 KB
Format:
Adobe Portable Document Format
Description:
Full text Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Biochemistry and Biotechnology