Gastrointestinal Carriage of Carbapenemase-Producing Enterobacterales among Inpatient and Outpatient Children in Kenya
| dc.contributor.author | Githii, Susan | |
| dc.contributor.author | Maingi, John M. | |
| dc.contributor.author | Nyaga, Teresia | |
| dc.contributor.author | Ndungu, Cecilia | |
| dc.contributor.author | Nyongesa, Kelvin Wangira | |
| dc.contributor.author | Musyoki, Abednego Moki | |
| dc.date.accessioned | 2025-01-13T09:10:08Z | |
| dc.date.available | 2025-01-13T09:10:08Z | |
| dc.date.issued | 2024-12 | |
| dc.description | Article | |
| dc.description.abstract | Gastrointestinal carriage of antimicrobial-resistant bacteria, especially carbapenemase-producing Enterobacterales (CPE), presents a critical public health threat globally. However, in many resource-constrained countries, epidemiological data on CPE is limited. Here, we assessed gastrointestinal carriage and associated factors of CPE among inpatient and outpatient children (≤ 5 years). This hospital-based cross-sectional study was conducted at Thika Level 5 Hospital in Kenya from February to June 2023. In total, 540 participants were recruited from outpatient (270) and inpatient (270) children, excluding those admitted for < 48 h and outpatients with ≤ 3 months hospitalization history. Demographic data were collected using a questionnaire, and stool or swab samples were cultured following standard microbiology methods. Automated platforms were used for isolates identification and antimicrobial susceptibility testing. Gastrointestinal carriage rate of CPE was 9.6%, 95% confidence interval (CI): 6.39–13.79% (26/270) among the inpatients and 5.9%, 95% CI: 3.42–9.45% (16/270) among the outpatients. The carbapenemase-producing Enterobacterales were predominated by multidrug-resistant Escherichia coli from inpatients (22/22, 100%) and outpatients (8/10, 80%). The colonization rate was higher among inpatients who were presenting with chills (aOR = 10.57, p = 0.008). We report a high gastrointestinal carriage of CPE among children (≤ 5 years). Strict adherence to colonization screening, and antimicrobial stewardship policies are critical to control CPE dissemination in the current study area and beyond. | |
| dc.identifier.citation | Githii, S., Maingi, J. M., Nyaga, T., Ndungu, C., Nyongesa, K. W., & Musyoki, A. M. (2024). Gastrointestinal carriage of carbapenemase-producing enterobacterales among inpatient and outpatient children in Kenya. Scientific Reports, 14(1), 30684. | |
| dc.identifier.uri | https://doi.org/10.1038/s41598-024-78059-1 | |
| dc.identifier.uri | https://ir-library.ku.ac.ke/handle/123456789/29417 | |
| dc.language.iso | en | |
| dc.publisher | Springer Nature | |
| dc.title | Gastrointestinal Carriage of Carbapenemase-Producing Enterobacterales among Inpatient and Outpatient Children in Kenya | |
| dc.type | Article |