Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment

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dc.contributor.authorKihara, Jimmy H.
dc.contributor.authorNjagi, E.N.M.
dc.contributor.authorKenya, E.U.
dc.contributor.authorMwanje, Marium T.
dc.contributor.authorOdek, Adel E.
dc.contributor.authorGovert, van Dam
dc.contributor.authorKahama, Anthony I.
dc.contributor.authorOuma, J. H.
dc.date.accessioned2012-11-02T12:54:14Z
dc.date.available2012-11-02T12:54:14Z
dc.date.issued2009-10
dc.description.abstractSchistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4–18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group ≤5 years compared with 6–8 years, 9–11 years and 12–14 years, and age group ≥15 years compared with 6–8 years, 9–11 years and 12–14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group ≤5 years compared with 9–11 years, 12–14 years and ≥15 years, and age group ≥15 years compared with 9–11 years and 12–14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r2=0.961, P=0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis.en_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene Volume 103, Issue 10 , Pages 1024-1030, October 2009en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/5931
dc.language.isoenen_US
dc.publisherThe Royal Society of Tropical Medicine & Hygieneen_US
dc.subjectSchistosoma haematobiumen_US
dc.subjectSoluble egg antigenen_US
dc.subjectPraziquantelen_US
dc.subjectSchoolchildrenen_US
dc.subjectSexen_US
dc.subjectKenyaen_US
dc.titleUrinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatmenten_US
dc.typeArticleen_US
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