Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)
| dc.contributor.author | Hassanali, Ahmed | |
| dc.contributor.author | Omole, R. A. | |
| dc.contributor.author | Gathirwa, J. | |
| dc.contributor.author | Akala, H. | |
| dc.contributor.author | Malebo, H. M. | |
| dc.contributor.author | Machocho, Alex K. | |
| dc.contributor.author | Ndiege, I. O. | |
| dc.date.accessioned | 2014-04-16T08:32:12Z | |
| dc.date.available | 2014-04-16T08:32:12Z | |
| dc.date.issued | 2014-04-12 | |
| dc.description | http://dx.doi.org/10.1016/j.phytochem.2014.03.026 | en_US |
| dc.description.abstract | From the leaves of Stephania abyssinica, three alkaloids were isolated: (−)-pseudocurine (1), (−)-pseudoisocurine (2) and (−)-10-oxoaknadinine (3). (−)-Pseudocurine and (-)-pseudoisocurine showed strong anti-plasmodial activity against both chloroquine-susceptible D6 and resistant strains of Plasmodium falciparum (IC50 0.29 ± 0.00 and 0.31 ± 0.01 μg/ml, respectively) while (−)-pseudoisocurine exhibited moderate and mild activity (0.75 ± 0.11 and 1.65 ± 0.03 μg/ml). | en_US |
| dc.identifier.citation | Phytochemistry Available online 12 April 2014 | en_US |
| dc.identifier.issn | 1873-3700 | |
| dc.identifier.issn | 0031-9422 | |
| dc.identifier.uri | http://ir-library.ku.ac.ke/handle/123456789/9379 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | Menispermerceae | en_US |
| dc.subject | Stephania abyssinica | en_US |
| dc.subject | Alkaloids | en_US |
| dc.subject | Bisbenzylisoquinoline | en_US |
| dc.subject | (−)-Pseudocurine and (−)-pseudoisocurine | en_US |
| dc.subject | Hasubanane | en_US |
| dc.subject | (−)-10-oxoaknadinine anti-plasmodial activity | en_US |
| dc.title | Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae) | en_US |
| dc.type | Article | en_US |