Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)
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Date
2014-04-12
Authors
Hassanali, Ahmed
Omole, R. A.
Gathirwa, J.
Akala, H.
Malebo, H. M.
Machocho, Alex K.
Ndiege, I. O.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
From the leaves of Stephania abyssinica, three alkaloids were isolated: (−)-pseudocurine (1), (−)-pseudoisocurine (2) and (−)-10-oxoaknadinine (3). (−)-Pseudocurine and (-)-pseudoisocurine showed strong anti-plasmodial activity against both chloroquine-susceptible D6 and resistant strains of Plasmodium falciparum (IC50 0.29 ± 0.00 and 0.31 ± 0.01 μg/ml, respectively) while (−)-pseudoisocurine exhibited moderate and mild activity (0.75 ± 0.11 and 1.65 ± 0.03 μg/ml).
Description
http://dx.doi.org/10.1016/j.phytochem.2014.03.026
Keywords
Menispermerceae, Stephania abyssinica, Alkaloids, Bisbenzylisoquinoline, (−)-Pseudocurine and (−)-pseudoisocurine, Hasubanane, (−)-10-oxoaknadinine anti-plasmodial activity
Citation
Phytochemistry Available online 12 April 2014