Mitochondrial haplogroups associated with elite Kenyan athlete status

Simple item page
dc.contributor.authorScott, Robert A
dc.contributor.authorFuku, Noriyuki
dc.contributor.authorOnywera, V.O.
dc.contributor.authorBoit, Michael K.
dc.contributor.authorWilson, Richard H
dc.contributor.authorTanaka, Masashi
dc.contributor.authorGoodwin, William H
dc.contributor.authorPitsiladis, Yannis P
dc.date.accessioned2013-05-03T08:18:22Z
dc.date.available2013-05-03T08:18:22Z
dc.date.issued2008-12
dc.description10.1249/MSS.0b013e31818313a2 pp.123-8en_US
dc.description.abstractThe maternal inheritance of mitochondrial DNA (mtDNA) has enabled construction of detailed phylogenies. Analysis of key polymorphisms from these phylogenies allows mtDNA to be assigned to haplogroups, which have been associated with elite endurance performance. To compare the frequencies of mtDNA haplogroups found in elite Kenyan athletes with those in the general Kenyan population. DNA samples were obtained from 221 national level Kenyan athletes (N), 70 international Kenyan athletes (I), and 85 members of the general Kenyan population (C). mtDNA haplogroups were classified by sequencing 340 bases of hypervariable section (HVS I) and by genotyping known restriction sites. Frequency differences between groups were assessed using exact tests of population differentiation. The haplogroup distribution of national (P = 0.023) and international athletes (P < 0.001) differed significantly from controls, with international athletes showing a greater proportion of L0 haplogroups (C = 15%, N = 18%, I = 30%) and lower proportion of L3* haplogroups (C = 48%, N = 36%, I = 26%). Although a high number of international athletes originated from the Rift Valley province relative to controls (C = 20%, N = 65%, I = 81%), subjects from this province did not differ in haplogroup distribution from other regions (P = 0.23). Nor did Bantu subjects differ from Nilotic (P = 0.12) despite an overrepresentation of Nilotic languages among the athletes. International athletes differed in their mtDNA haplogroup distribution relative to the general Kenyan population. They displayed an excess of L0 haplogroups and a dearth of L3* haplogroups. These findings suggest that mtDNA haplogroups are influential in elite Kenyan distance running, although population stratification cannot be ruled out.en_US
dc.identifier.citationMedicine and Sport Science(impact factor: 3.71). 12/2008; 41(1):123-8en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/6738
dc.language.isoenen_US
dc.publisherMedicine and Sport Scienceen_US
dc.titleMitochondrial haplogroups associated with elite Kenyan athlete statusen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Mitochondrial Haplogroups Associated with.pdf
Size:
228.49 KB
Format:
Adobe Portable Document Format
Description:
Full text article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
5.24 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Biochemistry and Biotechnology