Prevalence and Endoscopic Findings of Helicobacter pylori Infection among Dyspeptic Patients in Kenya
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Date
2020-12
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Scientific Research Publishing
Abstract
Background: Helicobacter pylori is the most common cause of chronic human
infections worldwide with the highest reported prevalence in Africa. It is
associated with numerous upper gastrointestinal diseases such as gastritis,
peptic ulcers, and gastric cancer. Endoscopic findings in the stomach usually
associated with Helicobacter pylori infections include gastritis and gastro-
esophageal reflux disease (GERD), however, these findings are suggestive
but not diagnostic of Helicobacter pylori infection. Methods: This was a
prospective study conducted between January 2018 and February 2019 at the
Aga Khan University Hospital where dyspeptic patients scheduled for gastroduodenoscopy
were enrolled. These patients were evaluated for Helicobacter
pylori infection by rapid urease test, culture and histopathology. Diagnostic
findings and patient history collected from medical files were documented
and data analyzed. Results: A total of 487 dyspeptic patients undergoing
esophagogastroduodenoscopy (EGD) were enrolled in the study and
199 dyspeptic patients were positive for Helicobacter pylori infection. The
prevalence was 54.6% in males and 45.4% in females (p = 0.1546. The most
common clinical indication and endoscopic findings were heart burn (25.2%)
and gastritis (53.7%). Histopathology revealed that 86.1% of the dyspeptic patients
had chronic active gastritis (p < 0.005) and 52.8% of them had H. pylori
infection. Conclusions: Classical endoscopic findings such as GERD are not
always indicative of H. pylori infection as its association with H. pylori infection was not statistically significant in this study.
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Ogalo, A., & Rugami, J., (2023). Positioning Strategies and Competitive Advantage of Tier One Banks in Mombasa County, Kenya. International Journal of Business Management, Entrepreneurship and Innovation , 5(3), 106-124. https://doi.org/10.35942/axveh492