Anti-retroviral drug hepatotoxicity and risk factors in HIV Patients with or without Hepatitis B and C : a review

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dc.contributor.authorWambani, J.R.
dc.contributor.authorOgola, P.E.
dc.contributor.authorArika, W.M.
dc.contributor.authorRachuonyo, H.O.
dc.contributor.authorKemboi, N.G.
dc.contributor.authorLihana, R.
dc.contributor.authorBurugu, M.W.
dc.date.accessioned2016-02-22T12:55:44Z
dc.date.available2016-02-22T12:55:44Z
dc.date.issued2015
dc.descriptionResearch paperen_US
dc.description.abstractPhysicians are treating patients infected with human immunodeficiency virus and/or hepatitis B or hepatitis C in their practice more often. Long-term complications of this diseases are multifactorial and can be related to the virus itself or to adverse effects of antiretroviral therapy. The liver is the main organ for regulating the internal environment of a body. There is no way to compensate for the loss of a liver function. It has major influences on the flow of nutrients as well as controlling carbohydrate, protein and fat metabolism. Drugs are significant in causing liver injury. More than nine hundred drugs, herbs and toxins have been documented as being hepatotoxic in line with different risk factors. The incidences of severe hepatic injury vary among different study cohorts as well as the differences in risk factors. Patients with a co-infection of HIV and Hepatitis B or C are at a risk of getting liver injury from antiretroviral drugs because the co-infections accelerate liver injury that may lead to cirrhosis or hepatocellular carcinoma. The risk of liver damage for those with a monoinfection of HIV alone is lower than in co-infections. This review explores risk factors for hepatotoxicity, its hepatotoxic antiretroviral drugs and the mechanisms of toxicity. It is meant to highlight the hepatotoxic potential of different antiretroviral drugs currently in use by HIV infected individualsen_US
dc.identifier.citationWambani JR, Ogola PE, Arika WM, Rachuonyo HO, Kemboi NG, et al. (2015) Anti-Retroviral Drug Hepatotoxicity and Risk Factors in HIV Patients with or Without Hepatitis B and C: A Review. J Infect Dis Ther 3: 258. doi:10.4172/2332-0877.1000258en_US
dc.identifier.issn2332-0877
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14228
dc.publisherAdis, Springer Healthcareen_US
dc.subjectHepatotoxicityen_US
dc.subjectAntiretroviral drugsen_US
dc.subjectRisk factorsen_US
dc.subjectMechanismsen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Cen_US
dc.subjectHepatotoxic potentialen_US
dc.subjectCoinfectionsen_US
dc.titleAnti-retroviral drug hepatotoxicity and risk factors in HIV Patients with or without Hepatitis B and C : a reviewen_US
dc.typeArticleen_US
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