Phytochemical and Anti-Inflammatory Analysis of Prunus africana Bark Extract

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dc.contributor.authorMutuma, Gitonga Godfrey
dc.contributor.authorNgeranwa, Joseph
dc.contributor.authorMachocho, Alex King’ori
dc.contributor.authorKiruki, Silas
dc.date.accessioned2020-10-05T10:00:13Z
dc.date.available2020-10-05T10:00:13Z
dc.date.issued2020
dc.descriptionA research article published in Research Journal of Pharmacognosyen_US
dc.description.abstractBackground and objectives: Inflammation is associated with various diseases; Prunus africana (Hook f.) is commonly used in Meru community of Kenya in management of inflammation. Medicinal plants contain phytochemicals associated with pharmacological activities; so, the aim of the present study was evaluating the anti-inflammatory activity of Prunus africana bark extract and qualitative analysis phytochemical of its phytochemicals. Methods: Five hundred mg of the powdered P. africana stem bark was extracted using 1.5 liters of dichloromethane for 24 h. The anti- inflammatory activity was evaluated against carrageenan paw induced edema in mice. The ability of the extracts to suppress the paw inflammation was expressed as a percentage inhibition of paw edema in five groups each comprising of five mice. Group I was treated with DMSO, group II with diclofenac (100 mg/Kg) and experimental groups III, IV and V with 50, 100 and 150 mg/Kg of the plant extract. The ability of the extracts to suppress the paw inflammation was expressed as a percentage inhibition of paw edema in mice. The qualitative phytochemical analysis was conducted using the standard protocols. Results: The percentages paw edema inhibition after the 4th h in the positive control and the experimental groups I, II and III were 13.61, 32.85, 25.15 and 5.92%, respectively. The qualitative evaluation of stem bark extract illustrated presence of tannins, saponins, flavonoids, alkaloids, quinones, cardiac glycosides, terpenoids, phenolics and coumarins. Conclusion: Dichloromethane stem bark extract of the P. africana presented anti-inflammatory activity hence a possible candidate for extraction of active anti-inflammatory compounds.en_US
dc.identifier.citationMutuma GG, Joseph N, King’ori MA, Silas K. Phytochemical and anti-inflammatory analysis of Prunus africana bark extract. Res J Pharmacogn. 2020; 7(4): 31-38.en_US
dc.identifier.issn2345-5977
dc.identifier.urihttp://www.rjpharmacognosy.ir/article_113661_7a6ef285246815770b2ad69b7b85281c.pdf
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/20519
dc.language.isoenen_US
dc.publisherResearch Journal of Pharmacognosyen_US
dc.subjectdiclofenacen_US
dc.subjectinflammationen_US
dc.subjectmiceen_US
dc.subjectphytochemistryen_US
dc.subjectPrunus africanaen_US
dc.titlePhytochemical and Anti-Inflammatory Analysis of Prunus africana Bark Extracten_US
dc.typeArticleen_US
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