Cognition Enhancing Potential of Aqueous Leaf Extract of Amaranthus dubius in Mice
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Date
2023
Authors
Kipkemoi, Daisy Jepkosgei
Ireri, Anthony Murithi
Ngugi, Mathew Piero
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE
Abstract
Amaranthus dubius is a vegetable consumed for its nutritional content in Kenya. In herbal medicine, A. dubius is utilized to relief
fever, anemia and hemorrhage. Additionally, it is utilized to manage cognitive dysfunction and is considered to augment brain function, but there is no empirical evidence to support this claim. The contemporary study investigated cognitive enhancing potential
of A. dubius in mice model of Alzheimer’s disease (AD)-like dementia induced with ketamine. Cognitively damaged mice were
treated with aqueous extract of A. dubius leaf upon which passive avoidance task (PAT) was used to assess the cognitive performance. At the end of passive avoidance test, brains of the mice were dissected to evaluate the possibility of the extract to inhibit
hallmarks that propagate AD namely oxidative stress and acetylcholinesterase activity. Additionally, characterization of secondary
metabolites was done using liquid chromatograph- mass spectrometry analysis. During PAT test, extract-treated mice showed
significantly increased step-through latencies than AD mice, depicting ability of A. dubius to reverse ketamine-induced cognitive
decline. Further, the extract remarkably lowered malondialdehyde levels to normal levels and effectively inhibited acetylcholinesterase enzyme. The study showed that A. dubius extract is endowed with phytoconstituents that possess anti-oxidant and anticholinesterase activities. Thus, this study confirmed promising therapeutic effects of 200, 300 and 400 mg/kg bw of A. dubius
extract with potential to alleviate cognitive disarray observed in AD.
Description
Article
Keywords
Amaranthus dubius, Alzheimer’s disease, passive avoidance, acetylcholinesterase and malondialdehyde
Citation
Kipkemoi, D. J., Ireri, A. M., & Ngugi, M. P. (2023). Cognition Enhancing Potential of Aqueous Leaf Extract of Amaranthus dubius in Mice. Journal of Evidence-Based Integrative Medicine, 28, 2515690X231211661.