Protection against Cutaneous Leishmaniasis in Outbred Vervet Monkeys, Using a Recombinant Histone H1 Antigen

Simple item page
dc.contributor.authorSlavica, Masina
dc.contributor.authorGicheru, Michael M.
dc.contributor.authorStéphane, O
dc.contributor.authorDemotz., Nicolas
dc.contributor.authorFasel, J.
dc.date.accessioned2014-09-15T09:15:07Z
dc.date.available2014-09-15T09:15:07Z
dc.date.issued2002-05
dc.descriptionPresented in part: 6th Annual Woods Hole Immunoparasitology Conference, Marine Biological Laboratory, Woods Hole, Massachusetts, 28 April–1 May 2002 (abstract 51)en_US
dc.description.abstractInfection with Leishmania major parasites results in the development of cutaneous ulcerative lesions on the skin. We investigated the protective potential of a single, recombinant histone H1 antigen against cutaneous leishmaniasis in an outbred population of vervet monkeys, using Montanide adjuvant. Protection was assessed by challenging the animals with a mixture of vector sand fly salivary-gland lysate and a low dose of in vitro–derived parasites, thus more closely mimicking natural infection induced by L. major. The course of infection in immunized monkeys was compared with that of animals that had healed from a primary infection and were immune. The monkeys immunized with recombinant histone H1 showed a reduced development of lesion size, compared with controls. Our study therefore illustrates the potential use of histone H1 as a vaccine candidate against cutaneous leishmaniasis in humansen_US
dc.description.sponsorshipFinancial support: RMF Dictagene; Fonds National de la Recherche Scientifique (grant 31-59450.99 to N.J.F.); Foundation Recherche and Santé (grant to S.M.)en_US
dc.identifier.citationThe Journal of Infectious Diseases Volume 188, Issue 8 Pp. 1250-1257en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11240
dc.language.isoenen_US
dc.publisherJournal of Infectious Diseasesen_US
dc.titleProtection against Cutaneous Leishmaniasis in Outbred Vervet Monkeys, Using a Recombinant Histone H1 Antigenen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Protection against Cutaneous Leishmaniasis in Outbred Vervet Monkeys, Using a Recombinant Histone H1 Antigen.pdf
Size:
54.09 KB
Format:
Adobe Portable Document Format
Description:
Abstract
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Zoological Sciences