2-Hydroxy-4-Methoxybenzaldehyde: Larvicidal Structure-Activity Studies
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Date
2005
Authors
Ndiege, Isaiah O
Lwande, Wilber
Akenga, Teresa O
Mahanga, Geoffrey M.
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Abstract
2-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD5022 mg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD5010, 9, 4.8, 1.2 mg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 mg/mL) as 1.
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Keywords
2-Hydroxy-4-methoxybenzaldehyde,, Larvicides,, Structure-activity relationships,, 2-Hdroxybenzaldehyde,, 2-Benzyloxybenzaldehyde,, Benzylphenyl ether Anopheles gambiae,
Citation
Journal Home Vol 19, No 1 (2005)