Anti-Inflammatory Properties of Methanolic Bark Extracts of Terminalia Brownii in Wistar Albino Rats

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dc.contributor.authorMbiri, J.W.
dc.contributor.authorSichangi, K.
dc.contributor.authorKisangau, P.
dc.contributor.authorWilton, M.
dc.contributor.authorNgugi, M.P.
dc.date.accessioned2016-07-21T08:12:45Z
dc.date.available2016-07-21T08:12:45Z
dc.date.issued2016
dc.descriptionResearch Articleen_US
dc.description.abstractObjective: This study investigated the anti-inflammatory properties of methanolic bark extract of Terminalia brownii in Wistar albino rats (Rattus novegicus). Methods: The experimental animals were divided into six groups of five rats each; normal control, negative control, positive control and three experimental groups. Carrageenan was used to induce inflammation. Diclofenac was used as the reference drug, and the three experimental groups were treated with the extract at the dose levels of 50, 100 and 150 mg/kg bw. The extract was screened for the presence or absence of selected phytochemical secondary metabolites using standard procedures. Results: The methanolic bark extracts of T. brownii significantly [p ˂ 0.05] reduced the carrageenan-induced paw edema by between 1.57%-20.41% while diclofenac reduced it by between 11.12%-25.33%. Phytochemical screening of the extract indicated the presence of alkaloids, flavonoids, phenols, saponins, steroids and terpenoids. Conclusion: The present study revealed that T. brownii bark extract is a potential candidate for the development of a novel anti-inflammatory formulation.en_US
dc.identifier.citationInternational Journal of Current Pharmaceutical Research Vol 8, Issue 3, 2016en_US
dc.identifier.issn0975-7066
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/14845
dc.language.isoenen_US
dc.publisherInnovare Academic Sciencesen_US
dc.subjectTerminalia browniien_US
dc.subjectMethanolic bark extractsen_US
dc.subjectAnti-inflammatory activityen_US
dc.titleAnti-Inflammatory Properties of Methanolic Bark Extracts of Terminalia Brownii in Wistar Albino Ratsen_US
dc.typeArticleen_US
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