Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

Simple item page
dc.contributor.authorOkwemba, R. I.
dc.contributor.authorTarus, P. K.
dc.contributor.authorMachocho, A. K.
dc.contributor.authorWanyonyi, A. W.
dc.contributor.authorWaweru, I. M.
dc.contributor.authorOnyancha, J. M.
dc.contributor.authorOnani, M. O.
dc.contributor.authorAmuka, O.
dc.date.accessioned2018-05-21T08:44:05Z
dc.date.available2018-05-21T08:44:05Z
dc.date.issued2018
dc.descriptionResearch Articleen_US
dc.description.abstractA novel prenylfuroquinoline alkaloid capensenin (1), an alkaloid confusameline (2), two furanocoumarins psolaren (3) and bergapten (4), were isolated from hexane and dichloromethane crude extracts of stem bark, leaves and fruit pericarp of Calodendrum capense. Limonin (5) was also isolated from the stem bark, while limonin diosphenol (6) was isolated from the seeds. Capensenin (1) showed weak antimicrobial activity against Bacillus subtilis, while the leaves, stem bark and fruit pericarp crude extracts exhibited activity against Staphylococcus aureus, B. subtilis and P. citrinum. Hexane pericarp extract showed slight cytotoxicity to Vero cell E199 in 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. The structures of the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and infra-red spectroscopyen_US
dc.identifier.issn1996-0875
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/18411
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectCapenseninen_US
dc.subject4-hydroxyfuroquinolineen_US
dc.subjectFuranocoumarinen_US
dc.subjectCalodendrum capenseen_US
dc.subjectAlkaloiden_US
dc.subjectRutaceaeen_US
dc.titleIsolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Isolation, characterization and biological....pdf
Size:
1.15 MB
Format:
Adobe Portable Document Format
Description:
Full Text Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Biochemistry and Biotechnology