Anti-inflammatory activity of methanolic leaf extract of Kigelia Africana (Lam.) benth and stem bark extract of acacia hockii de wild in mice
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Date
2016-06
Authors
Kamau, J. K.
Nthiga, P. M.
Mwonjoria, J. K.
Ngeranwa, J.J.N.
Ngugi, M. P.
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Abstract
Inflammation causes discomfort, suffering and lower productivity of the victims. Synthetic anti-inflammatory drugs
are not readily available and have adverse side effects. Alternative herbal medicines possess bioactive compounds
that are safer and efficient in the management of various diseases and disorders. The present study evaluated for
the anti-inflammatory activity of methanolic extracts of Kigelia africana and Acacia hockii in mice to scientifically
validate their traditional use among the Embu and Mbeere communities in Kenya. The plant samples were collected
with the help of local herbalists in Embu County, Kenya and transported to Kenyatta University biochemistry and
biotechnology laboratories for cleaning, air drying, milling, and extraction. Swiss albino mice of either sex were
randomly divided into six groups of 5 animals each; normal control, negative control, positive control and three
experimental groups. The anti-inflammatory activity was tested using carrageenan-induced hind paw edema
method. The anti-inflammatory activity of the extracts was compared to reference drug diclofenac. The leaf extract of
K. africana reduced inflamed hind paw diameter of mice by between 0.21%- 4.98% while the stem bark extract of A.
hockii reduced inflamed hind paw diameter by between 0.6%-5.38%. The diclofenac reduced inflamed hind paw
diameter by between 1.11%-4.9%. The qualitative phytochemical screening indicated the presence of saponins,
flavonoid, alkaloids, terpenoids, phenolics, and cardiac glycosides. The present study demonstrated potent antiinflammatory
activities of methanolic extracts of K. africana and A. hockii in a dose-dependent manner, which
supports their traditional use. The present study, therefore, recommends the ethnomedicinal use of K. africana and
A. hockii in the management of inflammation.
Description
http://dx.doi.org/10.4172/2329-6631.1000156
Keywords
Kigelia africana, Acacia hockii, Anti-inflammatory, PGE2, Paw edema
Citation
Journal of Developing Drugs, 2016, 5:2 http://dx.doi.org/10.4172/2329-6631.1000156