Insulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distribution

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dc.contributor.authorBoit, Michael K.
dc.contributor.authorChristensen, D.L.
dc.contributor.authorFaurholt-Jepsen, D.
dc.contributor.authorFaerch, K.
dc.contributor.authorMwaniki, D.L.
dc.contributor.authorKilonzo, B.
dc.contributor.authorTetens, I.
dc.contributor.authorFriis, H.
dc.date.accessioned2014-11-19T09:06:36Z
dc.date.available2014-11-19T09:06:36Z
dc.date.issued2014
dc.descriptiondoi: 10.1007/s00592-013-0474-xen_US
dc.description.abstractLittle is known about the pathophysiology of diabetes in Africans. Thus, we assessed whether insulin resistance and beta-cell function differed by ethnicity in Kenya and whether differences were modified by abdominal fat distribution. A cross-sectional study in 1,087 rural Luo (n = 361), Kamba (n = 378), and Maasai (n = 348) was conducted. All participants had a standard 75-g oral glucose tolerance test (OGTT). Venous blood samples were collected at 0, 30, and 120 min. Serum insulin was analysed at 0 and 30 min. From the OGTT, we assessed the homoeostasis model assessment of insulin resistance by computer model, early phase insulin secretion, and disposition index (DI) dividing insulin secretion by insulin resistance. Abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) thickness were carried out by ultrasonography. Linear regression analyses were done to assess ethnic differences in insulin indices. The Maasai had 32 and 17% higher insulin resistance than the Luo and Kamba, respectively (p < 0.001). Early phase insulin secretion was 16% higher in the Maasai compared to the Luo (p < 0.001). DI was 12% (p = 0.002) and 10% (p = 0.015) lower in the Maasai compared to the Luo and Kamba, respectively. Adjustments of SAT (range 0.1-7.1 cm) and VAT (range 1.5-14.2 cm) largely explained these inter-group differences with the Maasai having the highest combined abdominal fat accumulation. The Maasai had the highest insulin resistance and secretion, but the lowest relative beta-cell function compared to the Luo and Kamba. These differences were primarily explained by abdominal fat distribution.en_US
dc.identifier.citationActa Diabetologica February 2014, Volume 51, Issue 1, pp 53-60en_US
dc.identifier.issn0940-5429
dc.identifier.other1432-5233
dc.identifier.urihttp://link.springer.com/article/10.1007/s00592-013-0474-x#page-1
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11700
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.titleInsulin resistance and beta-cell function in different ethnic groups in Kenya: the role of abdominal fat distributionen_US
dc.typeArticleen_US
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