Effect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.

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dc.contributor.authorNdombi, E. M.
dc.contributor.authorAbudho, B.
dc.contributor.authorKittur, N.
dc.contributor.authorCarter, J. M.
dc.contributor.authorKorir, H.
dc.contributor.authorRiner, D.K
dc.contributor.authorOchanda, H.
dc.contributor.authorLee, Y-M
dc.contributor.authorSecor, W.E
dc.contributor.authorKaranja, D.M
dc.contributor.authorColley, D.G
dc.date.accessioned2023-03-27T13:26:48Z
dc.date.available2023-03-27T13:26:48Z
dc.date.issued2018
dc.descriptionArticleen_US
dc.description.abstractThis study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross-sectional study design, 210 schistosome egg-positive children were recruited at baseline from schools in western Kenya (baseline group). Another 251 children of the same age range were recruited from the same schools and diagnosed with schistosome infection by microscopy (post-MDA group). In-vitro schistosome-specific cytokines and plasma antibody levels were measured by ELISA and compared between the 2 groups of children. Schistosome soluble egg antigen (SEA) and soluble worm antigen preparation (SWAP) stimulated higher IL-5 production by egg-negative children in the post-MDA group compared to the baseline group. Similarly, anti-SEA IgE levels were higher in egg-negative children in the post-MDA group compared to the baseline group. Anti-SEA and anti-SWAP IgG4 levels were lower in egg-negative children in the post-MDA group compared to baseline. This resulted in higher anti-SEA IgE/IgG4 ratios for children in the post-MDA group compared to baseline. These post-MDA immunological changes are compatible with the current paradigm that treatment shifts immune responses to higher antischistosome IgE:IgG4 ratios in parallel with a potential increase in resistance to reinfection.en_US
dc.description.sponsorshipNIH Grant R01AI53695.en_US
dc.identifier.citationNdombi, E. M., Abudho, B., Kittur, N., Carter, J. M., Korir, H., Riner, D. K., ... & Colley, D. G. (2018). Effect of four rounds of annual school‐wide mass praziquantel treatment for schistosoma mansoni control on schistosome‐specific immune responses. Parasite Immunology, 40(6), e12530.en_US
dc.identifier.otherhttps://doi.org/10.1111/pim.12530
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/25018
dc.language.isoenen_US
dc.publisherWiley Online Libraryen_US
dc.subjectAntibodiesen_US
dc.subjectCytokinesen_US
dc.subjectMass Drug Administrationen_US
dc.subjectPraziquantelen_US
dc.subjectSchistosomiasisen_US
dc.subjectSchool-Based Treatmenten_US
dc.titleEffect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.en_US
dc.typeRecording, musicalen_US
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