Effect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.
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Date
2018
Authors
Ndombi, E. M.
Abudho, B.
Kittur, N.
Carter, J. M.
Korir, H.
Riner, D.K
Ochanda, H.
Lee, Y-M
Secor, W.E
Karanja, D.M
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley Online Library
Abstract
This study evaluated potential changes in antischistosome immune responses in children
from schools that received 4 rounds of annual mass drug administration (MDA)
of praziquantel (PZQ). In a repeated cross-sectional
study design, 210 schistosome
egg-positive
children were recruited at baseline from schools in western Kenya
(baseline group). Another 251 children of the same age range were recruited from the
same schools and diagnosed with schistosome infection by microscopy (post-MDA
group). In-vitro
schistosome-specific
cytokines and plasma antibody levels were
measured by ELISA and compared between the 2 groups of children. Schistosome
soluble egg antigen (SEA) and soluble worm antigen preparation (SWAP) stimulated
higher IL-5
production by egg-negative
children in the post-MDA
group compared to
the baseline group. Similarly, anti-SEA
IgE levels were higher in egg-negative
children
in the post-MDA
group compared to the baseline group. Anti-SEA
and anti-SWAP
IgG4 levels were lower in egg-negative
children in the post-MDA
group compared to
baseline. This resulted in higher anti-SEA
IgE/IgG4 ratios for children in the post-MDA
group compared to baseline. These post-MDA
immunological changes are compatible
with the current paradigm that treatment shifts immune responses to higher
antischistosome IgE:IgG4 ratios in parallel with a potential increase in resistance to
reinfection.
Description
Article
Keywords
Antibodies, Cytokines, Mass Drug Administration, Praziquantel, Schistosomiasis, School-Based Treatment
Citation
Ndombi, E. M., Abudho, B., Kittur, N., Carter, J. M., Korir, H., Riner, D. K., ... & Colley, D. G. (2018). Effect of four rounds of annual school‐wide mass praziquantel treatment for schistosoma mansoni control on schistosome‐specific immune responses. Parasite Immunology, 40(6), e12530.