Analgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Mice

Simple item page
dc.contributor.authorKoech, S.C
dc.contributor.authorOuko, R.O
dc.contributor.authorMichael, N.M
dc.contributor.authorIreri, M.M
dc.contributor.authorNgugi, M.P
dc.contributor.authorNjagi, N.M
dc.date.accessioned2021-02-24T11:25:33Z
dc.date.available2021-02-24T11:25:33Z
dc.date.issued2017
dc.descriptionA research paper published in Natural Products Chemistry & Researchen_US
dc.description.abstractPain as a sensory modality, represent a symptom for diagnosing various diseases and its associated conditions. Although it acts as a sensory modality in drawing attention to tissue injury, it is associated with poor quality of life and socioeconomic burden to the victim. Conventional synthetic drugs that are used to manage pain are not readily available and are associated with adverse effects. Thus, the use of herbal medicine from medicinal plants is an age old practice used by many communities to cure diseases. These medicinal plants are known to contain phytochemical compounds capable of relieving pain and healing diseases. C. abyssinica has been used traditionally by the Kallenjin community to alleviate various diseases. However, an extensive search of the literature reveals that no data has been documented about the medicinal use of the plant in suppressing pain. The present study thus, evaluated on analgesic potential of dichloromethanolic root extract of C. abyssinica in animal models. Thirty Swiss albino mice were grouped into six groups of five animal each; normal control, negative control, positive control and three experimental groups. The experimental animals were administered with the extract intraperitoneally at dose level of 50, 100 and 150 mg/ kg body weight. Acetic acid-induced pain was used to determine the analgesic activity of the extract. Diclofenac was used as a reference drug. The dichloromethanolic root extract reduced the number of abdominal writhing’s between 33.95% and 49.77% while the reference drug reduced the number of abdominal writhing’s by 46.51%. A number of phytochemical compounds associated with analgesic activity were observed to be present. The study therefore scientifically confirmed the traditional use of the medicinal plant in management of pain.en_US
dc.identifier.citationKoech, S. C., Ouko, R. O., Michael, N. M., Ireri, M. M., Ngugi, M. P., & Njagi, N. M. (2017). Analgesic activity of dichloromethanolic root extract of Clutia abyssinica in swiss albino mice. Nat Prod Chem Res, 5(255), 2.en_US
dc.identifier.issn2329-6836
dc.identifier.urihttps://www.longdom.org/open-access/analgesic-activity-of-dichloromethanolic-root-extract-of-clutia-abyssinicain-swiss-albino-mice-2329-6836-1000255.pdf
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/21578
dc.language.isoenen_US
dc.publisherLongdomen_US
dc.subjectPainen_US
dc.subjectC. abyssinicaen_US
dc.subjectHerbalen_US
dc.subjectMiceen_US
dc.titleAnalgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Miceen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
analgesic-activity-of-dichloromethanolic-root-extract-of-clutia-abyssinicain-swiss-albino-mice-2329-6836-1000255.pdf
Size:
530.26 KB
Format:
Adobe Portable Document Format
Description:
Full text article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Biochemistry and Biotechnology