Alterations on Peripheral B cell Subsets following an Acute Uncomplicated Clinical Malaria Infection in Children
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Date
2008-11
Authors
Asito, A. S.
Moormann, A. M.
Kiprotich, C.
Ng'ang'a, Z. W.
Ploutz-Snyder, R.
Rochford, R.
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central Ltd.
Abstract
BACKGROUND:
The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype.
METHODS:
Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls.
RESULTS:
There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of IgD and CD38 revealed a significant decrease in the numbers of naive 1 CD38-IgD+ B cells while there was an increase in CD38+IgD- memory 3 B cells during acute malaria. Further analysis of the peripheral B cell phenotype also identified an expansion of transitional CD10+CD19+ B cells in children following an episode of acute malaria with up to 25% of total CD19+ B cell pool residing in this subset.
CONCLUSION:
Children experiencing an episode of acute uncomplicated clinical malaria experienced profound disturbances in B cell homeostasis.
Description
doi:10.1186/1475-2875-7-238
Keywords
Citation
Malaria Journal 2008, 7:238