Hypoglycemic Activity of Some Kenyan Plants Traditionally used to Manage Diabetes Mellitus in Eastern Province.
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Date
2011-11-19
Authors
Piero, N.M.
Joan, M.N.
Cromwell, K.M.
Joseph, N.J.
Wilson, N.M.
Daniel, M.M.
Peter, K.G.
Njagi, E.N.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Diabetes and Metabolism
Abstract
In this study five aqueous extracts; Bidens pilosa, StrychnoS.henningsii, Aspilia pluriseta, Catha edulis and Erythrina abyssinica were screened for anti-diabetic activity and their in vivo safety evaluated. The anti-diabetic activity was assessed by intraperitoneally injecting varying doses of aqueous extracts of the five plants into alloxanised mice. Toxicity was determined by injecting normal mice with 450mg of the plant extract / kg body weight and observing the effects of the extracts on histology of various organs. All the extracts showed hypoglycaemic activity. At high doses, some plants proved to be highly toxic, mildly toxic and others were safe. This study has established that the five bioactive plants can be safely used in the management of diabetes.
Description
doi:10.4172/2155-6156.1000155
Keywords
Anti-diabetic activity, in vivo toxicity; Histology, Alloxanised mice
Citation
Journal of Diabetes and Metabolism, 2:155.