Reverse Transcriptase Inhibitors Drug Resistance Mutations in Drug-Naive HIV Type 1 Positive Kenyan Individuals
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Date
2011
Authors
Nyamache, A. K.
Waihenya, R.
Muigai, A. W.
Khamadi, S. A.
Journal Title
Journal ISSN
Volume Title
Publisher
African Journals Online
Abstract
Objective: To evaluate the extent of HIV-1 drug resistance among drug naïve Kenyan individuals.
Design: Cross-sectional study.
Setting: Kenya Medical Research Institute HIV laboratory Nairobi, Kenya.
Subjects: A total of seventy eight HIV-1 positive drug naïve subjects randomised from five Kenyan provincial hospitals between April and June 2004.
Results: A major non-nucleoside reverse transcriptase (NNRTI) an associated mutation was found in one patient (1.3%). NNRTI associated resistance mutations were present at amino acid codon sites G98A (2.56%); K103E (1.3%) and L100F (3.57%) prevalences. Baseline resistance may compromise the response to standard NNRTI-based first-line ART in 1.3 % of the study subjects.
Conclusion: This indicates in general, that drug resistance among HIV-1 positive drug naïve individual is at low thresholds (1.3%) but the problem could be more serious than reported here. Continuous resistance monitoring is therefore warranted to maintain individual and population-level ART effectiveness.
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Citation
East African Medical Journal > Vol 88, No 1 (2011)