Reverse Transcriptase Inhibitors Drug Resistance Mutations in Drug-Naive HIV Type 1 Positive Kenyan Individuals

Simple item page
dc.contributor.authorNyamache, A. K.
dc.contributor.authorWaihenya, R.
dc.contributor.authorMuigai, A. W.
dc.contributor.authorKhamadi, S. A.
dc.date.accessioned2012-11-02T13:44:36Z
dc.date.available2012-11-02T13:44:36Z
dc.date.issued2011
dc.description.abstractObjective: To evaluate the extent of HIV-1 drug resistance among drug naïve Kenyan individuals. Design: Cross-sectional study. Setting: Kenya Medical Research Institute HIV laboratory Nairobi, Kenya. Subjects: A total of seventy eight HIV-1 positive drug naïve subjects randomised from five Kenyan provincial hospitals between April and June 2004. Results: A major non-nucleoside reverse transcriptase (NNRTI) an associated mutation was found in one patient (1.3%). NNRTI associated resistance mutations were present at amino acid codon sites G98A (2.56%); K103E (1.3%) and L100F (3.57%) prevalences. Baseline resistance may compromise the response to standard NNRTI-based first-line ART in 1.3 % of the study subjects. Conclusion: This indicates in general, that drug resistance among HIV-1 positive drug naïve individual is at low thresholds (1.3%) but the problem could be more serious than reported here. Continuous resistance monitoring is therefore warranted to maintain individual and population-level ART effectiveness.en_US
dc.identifier.citationEast African Medical Journal > Vol 88, No 1 (2011)en_US
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/5936
dc.language.isoenen_US
dc.publisherAfrican Journals Onlineen_US
dc.titleReverse Transcriptase Inhibitors Drug Resistance Mutations in Drug-Naive HIV Type 1 Positive Kenyan Individualsen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
REVERSE TRANSCRIPTASE INHIBITORS DRUG.pdf
Size:
281.79 KB
Format:
Adobe Portable Document Format
Description:
Full text article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
5.24 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
RP-Department of Plant and Microbial Sciences