The role of nitric oxide in non specific immunity to plasmodium falciparum malaria and Leishmania Donovani infections in residents of endemic areas in Kenya
Nitric oxide is a potent, non-specific molecule that can mediate activated macrophage cytotoxicity against a variety of intracellular and extracellular infectious agents. For example, it plays a role in host defense against Toxoplasma gondii, Leishmania major amastigotes, and Plasmodium species. The aim of this study was to determine whether serum nitric oxide levels in humans are related to the degree fo resistance or susceptibility to Plasmodium falciparum malaria and whether they correlate with the clinical course of Leishmania donavani infections. Nitric oxide levels in plasma were measured by reduction of its serum surrogates, nitrate to nitrite by Pseudomonas oleovarans nitrate reductase followed by a colorimetric quantitative measure of nitrite by the Greiss reaction. Malaria plasma samples were obtained from semi immune adults and non-immune children with cerebral malaria. Absolute parasitaemia in malaria patients was determined. Similarly, plasma samples from patients with kala-azar obtained and the nitric oxide levels obtained were correlated with the clinical course of leishmaniasis. It was found that nitric oxide production in individuals partly immune to malaria did not correlate with protective immunity (n=268; p>0.05). Futhermore serum nitrate levels in patients treated with antimalarial drugs, azithromycin and doxycycline were significantly different (n=25; t=6.964; p<0.001). Nitric oxide levels were significantly higher in individuals with cerebral malaria compared to those with the mild disease (n=9; t=1.8595; p<0.05). A transient elevation in serum nitric oxide correlated with disease with disease regression in Kala-azar.
- MST-Zoological Sciences 
Showing items related by title, author, creator and subject.
Factors affecting performance of tourism sector in Kenya. ( A case of Kenya Tourism Board, Bomas of Kenya, Kenya Utalii College and Kenya Wildlife Service) Okemwa, Ogwoka (2012-03-01)The main objective of this study was to look into the factors that affect performance of the tourism sector in Kenya. A sample of 27 respondents was drawn from Kenya Tourism Board. Bomas of Kenya Ltd., Kenya Wildlife Service ...
Factors Affecting Performance of Tourism Sector in Kenya (Case of Kenya Tourism Board, Bomas of Kenya, Kenya Utalii College and Kenya Wildlife Service) Ogwoka, Okemwa (Kenyatta University, 2005)The main objective of this study was to look into the factors that affect performance of the tourism sector in Kenya. A sample of 27 respondents was drawn from Kenya Tourism Board. Bomas of Kenya Ltd., Kenya Wildlife ...
Effects of Information Literacy on Adult Consumers of Kenya National Library Services in Embu County: A Case Study of the Kenya National Library Services Embu Branch, Embu County, Kenya Karimi, Phyllis Njeri (Kenyatta University, 2017-06)The study aimed at assessing the effects of information literacy programs on adult users in public libraries in Kenya by conducting a case study at Embu County public library. Public libraries have been operating with ...