Biochemical Markers Analysis for Sars-Cov-2 Infected Patients in Kakamega County, Kenya
Loading...
Date
2024-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kenyatta University
Abstract
Aims and objectives: Severe Acute respiratory syndrome corona virus 2(SARS-CoV-2)
is a type of coronavirus that first emerged in Wuhan, China late 2019. Once this virus
infects any person, it causes Coronavirus disease 2019 (COVID-19) capable of causing
death. Since then, hundreds of thousands of deaths have been reported as a result of
COVID-19 globally. It is critical to detect the people with the potential of becoming very
sick with COVID-19 early enough in order to save their lives by testing blood for certain
chemicals known as biomarkers. This study aimed to determine biochemical markers in
SARS-COV-2 infected patients in Kakamega County, Kenya. The Selected biochemical
markers LFT, RFT, electrolytes, blood glucose level C-reactive protein (CRP), lactate
dehydrogenase (LDH), were also evaluated for correlation with disease severity.
Materials and methods: A cross-sectional study was conducted on 350 patients with
COVID 19 attending Kakamega County general teaching and Referral Hospital. Ethical
approval was sought from Kenyatta University Ethical and research committee and
permission was obtained from Kakamega county general teaching and referral hospital
administration. Socio-demographic, clinical characteristics of covid-19 among admitted
patients in Kakamega Country Referral hospital was collected using a questionnaire.
Five (5ml) of venous blood was collected and analyzed using standard hematological
parameters profile, assessment of liver, renal and cardiac functions tests and evaluation of
High-sensitivity C-Reactive protein.
Results: A total of 350 patients were enrolled in the study. Majority of the participants
were male (52.9%, 185/350) while 165(47.1%) were female. Out of the 350 patients
recruited, 296 (84.6%) were Covid-19 positive while 44 (15.1%) were negative. This
indicated a high prevalence of 84.6% of Covid-19 among patents who attended the
facility during the study period. Data presentation was done using tables and figures and
analyzed using formula of Le and Boen, Chi square and Correlation tests.
Conclusions: Out of the 350 patients recruited, 296 (84.6%) were Covid-19 positive
while 44 (15.1%) were negative. This indicated a high prevalence of 84.6% of Covid-19
among patents who attended the facility during the study period. Biochemical markers of
the liver (ALT, AST), Total bilirubin, blood protein were elevated among Covid-19
positive patients, while albumin was low among Covid-19 negative patients.
Description
A Thesis Submitted in Partial Fulfillment of the Requirements for the Award of the Degree of Master of Science in Infectious Diseases in the School of Health Sciences, Kenyatta University July, 2024
Supervisor:
1.Nelson C. Menza
2.Iddah M. Ali