In Vitro Antioxidant Activities of Carissa Edulis ((Forssk) Vahl) and Pappea Capensis (Eckyl. & Zeyh) Extracts
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Date
2023
Authors
Muruthi, Carolyn Wanjira
Ngugi, Mathew Piero
Runo, Steven Maina
Mwitari, Peter Githaiga
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Abstract
Herbal medications are gaining popularity due to their long history of use in traditional medicine. They serve as a reservoir for a diverse array of
phytocompounds linked to amelioration of oxidative stress. Oxidative stress is a disturbance in the balance between generation and elimination of
reactive species in human body. Moreover, reactive species are implicated in the onset and progression of chronic disorders. The current therapeutic
approaches despite showing efficacy are characterized by several limitations such as adverse effects and prohibitive costs. This drives the need to
explore alternatives that can inhibit, ameliorate or reverse conditions caused by oxidative stress. Several studies have evaluated antioxidant effects
of diverse plant extracts. C. edulis and P. capensis are used as traditional therapy among the African communities to manage oxidative stress-related
ailments. However, there is limited research on the antioxidant effects of these medicinal plants. The current study, therefore, sought to evaluate the
antioxidant and phytochemical profile, of C. edulis and P. capensis extracts. Samples were collected from Embu County, Kenya. In vitro antioxidant
properties of the extracts were evaluated through ferric reduction, Iron chelating, hydroxyl radical, and DPPH radical scavenging activities. Activities
of catalase, superoxide dismutase and glutathione reductases of the extracts were further determined. Phytochemical profiles were determined
using Liquid Chromatography Mass Spectrophotometer (LC-MS) and Gas Chromatography Mass Spectrophotometer (GC-MS) analyses. The
extracts displayed concentration dependent antioxidant activities. Phytochemical analyses revealed presence compounds which are associated with
antioxidant activities including flavonoids, phenolics, tocopherols and terpenoids. The findings provide a scientific validation for the folklore use of
C. edulis and P. capensis in management of oxidative stress. Nevertheless, there is a need for further purification and characterization of phytochemicals
associated with antioxidant activities.
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Muruthi, C. W., Ngugi, M. P., Runo, S. M., & Mwitari, P. G. (2023). In vitro antioxidant activities of Carissa edulis ((Forssk) Vahl) and Pappea capensis (Eckyl. & Zeyh) extracts. Heliyon, e12965.