Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors

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Date
2020Author
Olasunkanmi, Oluwatayo Israel
Chen, Sijia
Mageto, James
Zhong, Zhaohua
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Show full item recordAbstract
RNA granules, aggresomes, and autophagy are key players in the immune response to viral
infections. They provide countermeasures that regulate translation and proteostasis in order to rewire
cell signaling, prevent viral interference, and maintain cellular homeostasis. The formation of cellular
aggregates and inclusions is one of the strategies to minimize viral infections and virus-induced cell
damage and to promote cellular survival. However, viruses have developed several strategies to
interfere with these cellular processes in order to achieve productive replication within the host cells.
A review on how these mechanisms could function as modulators of cell signaling and antiviral
factors will be instrumental in refining the current scientific knowledge and proposing means whereby
cellular granules and aggregates could be induced or prevented to enhance the antiviral immune
response in mammalian cells