Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors

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dc.contributor.authorOlasunkanmi, Oluwatayo Israel
dc.contributor.authorChen, Sijia
dc.contributor.authorMageto, James
dc.contributor.authorZhong, Zhaohua
dc.date.accessioned2023-03-23T09:14:28Z
dc.date.available2023-03-23T09:14:28Z
dc.date.issued2020
dc.descriptionArticleen_US
dc.description.abstractRNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral interference, and maintain cellular homeostasis. The formation of cellular aggregates and inclusions is one of the strategies to minimize viral infections and virus-induced cell damage and to promote cellular survival. However, viruses have developed several strategies to interfere with these cellular processes in order to achieve productive replication within the host cells. A review on how these mechanisms could function as modulators of cell signaling and antiviral factors will be instrumental in refining the current scientific knowledge and proposing means whereby cellular granules and aggregates could be induced or prevented to enhance the antiviral immune response in mammalian cellsen_US
dc.description.sponsorshipNational Natural Science Foundation of Chinaen_US
dc.identifier.citationOlasunkanmi, O. I., Chen, S., Mageto, J., & Zhong, Z. (2020). Virus-induced cytoplasmic aggregates and inclusions are critical cellular regulatory and antiviral factors. Viruses, 12(4), 399.en_US
dc.identifier.other10.3390/v12040399
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/24998
dc.language.isoenen_US
dc.publisherPubmed Centralen_US
dc.subjectRNA granulesen_US
dc.subjectaggresomeen_US
dc.subjectautophagyen_US
dc.subjectproteostasisen_US
dc.titleVirus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factorsen_US
dc.typeArticleen_US
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